FDA Approves Austedo XR Extended-Release Tablets for Huntington’s Disease

Title: FDA Approves Austedo XR Extended-Release Tablets for Huntington’s Disease


In a significant milestone for patients with Huntington’s disease, the U.S. Food and Drug Administration (FDA) has granted approval for Austedo XR extended-release tablets. This approval marks an important development in the management of Huntington’s disease. In this blog post, we will focus on the key points surrounding the FDA’s approval and its potential implications for patients with Huntington’s disease.

Key Points

  1. Understanding Huntington’s Disease: Huntington’s disease is a rare, inherited neurodegenerative disorder that causes the progressive breakdown of nerve cells in the brain. It is characterized by motor disturbances, cognitive decline, and psychiatric symptoms. Huntington’s disease significantly impacts an individual’s ability to function independently and has a profound effect on their quality of life.
  2. Austo XR: The First Approved Treatment: The FDA’s approval of Austedo XR marks the first approved treatment specifically indicated for patients with Huntington’s disease. Austedo XR is an extended-release form of the drug deutetrabenazine, which is a vesicular monoamine transporter 2 (VMAT2) inhibitor. By targeting the VMAT2 protein, Austedo XR helps to regulate the levels of certain neurotransmitters in the brain, which can alleviate the abnormal movements associated with Huntington’s disease.
  3. Efficacy and Safety: Clinical Trials: The FDA approval of Austedo XR was based on robust clinical trials that demonstrated the drug’s efficacy and safety in reducing chorea, a characteristic symptom of Huntington’s disease. The trial results showed a significant reduction in chorea in patients treated with Austedo XR, thus improving their motor function and overall quality of life.
  4. Extended-Release Formulation: Benefits for Patients: Austedo XR’s extended-release formulation offers advantages over immediate-release formulations. With this extended-release tablet, patients only need to take one or two doses per day, providing convenience and potentially improving adherence to medication regimens. Additionally, the extended-release formulation offers a smoother and more consistent release of the active medication throughout the day, leading to more stable therapeutic effects.
  5. Expanding Treatment Options for Huntington’s Disease: The FDA’s approval of Austedo XR represents a significant advancement in the treatment of Huntington’s disease. Prior to this approval, there were limited options available to manage the motor symptoms associated with the disease. Austedo XR provides a targeted therapy that may help effectively control chorea and improve the quality of life for patients with Huntington’s disease.
  6. Holistic Approach to Care: While the approval of Austedo XR is a notable step forward, it is essential to recognize that Huntington’s disease is a complex condition requiring a multidisciplinary approach to care. Alongside medication, patients benefit from comprehensive support, including physical and occupational therapy, speech therapy, and psychological support to address the cognitive and psychiatric aspects of the disease.
  7. Hope for the Future: The FDA’s approval of Austedo XR represents progress in the field of Huntington’s disease treatment. It brings hope to patients, their families, and healthcare professionals, showcasing the commitment to finding effective therapies for this rare and devastating condition. Continued research and development in the field hold promise for improved treatments and, ultimately, a better quality of life for individuals living with Huntington’s disease.


The FDA’s approval of Austedo XR extended-release tablets for Huntington’s disease offers new hope to patients battling this rare neurodegenerative disorder. The availability of a targeted treatment option specifically designed to address the motor symptoms associated with Huntington’s disease represents a significant breakthrough in management. As research and medical advancements continue, it is vital to remain committed to comprehensive and multidisciplinary care approaches, ensuring that individuals with Huntington’s disease receive the support they need to enhance their overall well-being and quality of life.