Nona and Dragonfly Forge a Partnership in HCAb-based Drug Discovery


Nona, a leading biotechnology company, and Dragonfly, a pioneer in immunotherapy research, have recently joined forces to establish a groundbreaking partnership focused on HCAb-based drug discovery. This strategic collaboration presents a significant opportunity to leverage the unique capabilities of heavy chain only antibodies (HCAbs) in developing innovative therapeutics for a wide range of diseases. In this blog, we will explore the key points of Nona and Dragonfly‘s partnership and the potential implications for drug discovery and patient care.

Key Points:

  1. Harnessing the Power of HCAbs:
    • HCAbs are distinct antibody fragments found in camelids and cartilaginous fish, renowned for their unique characteristics and versatile applications in drug development.
    • Compared to conventional antibodies, HCAbs lack a light chain, resulting in smaller, single-domain antibody fragments that possess superior stability, solubility, and tissue penetration.
    • The binding domains of HCAbs can be engineered and optimized for a variety of therapeutic targets, making them valuable assets in drug discovery.
  2. Strategic Partnership Between Nona and Dragonfly:
    • Nona, a leading biotechnology company, recognized for its expertise in antibody research and development, has partnered with Dragonfly, an innovative immunotherapy research organization.
    • The collaboration aims to harness the potential of HCAbs by combining Nona’s extensive knowledge in antibody engineering and Dragonfly’s expertise in immuno-oncology and immunotherapy platforms.
    • Together, Nona and Dragonfly are poised to accelerate the discovery and development of advanced therapies using HCAb-based drug discovery techniques.
  3. Advantages of HCAb-based Drug Discovery:
    • HCAb-based drug discovery offers several advantages over traditional antibody-based approaches.
    • The smaller size of HCAbs enables improved tissue penetration, facilitating access to challenging targets, and potentially enhancing therapeutic efficacy.
    • HCAbs can be engineered for multispecific binding, allowing for simultaneous targeting of multiple disease-associated molecules, potentially enhancing treatment outcomes and versatility in addressing complex diseases.
  4. Broad Therapeutic Applications:
    • The partnership between Nona and Dragonfly in HCAb-based drug discovery holds promise for addressing a wide range of diseases, including cancer, autoimmune disorders, and infectious diseases.
    • HCAbs can target tumor-specific antigens, directly killing cancer cells, or modulate immune responses to enhance patient’s immune system against cancer.
    • In the realm of infectious diseases, HCAbs can be employed as potential therapeutics against viral and bacterial infections with their potent and specific neutralizing capabilities.
  5. Accelerating Drug Development:
    • The union of Nona and Dragonfly’s expertise offers potential acceleration of the drug discovery process through the focused application of HCAb technology.
    • Leveraging Nona’s antibody engineering capabilities and Dragonfly’s immunotherapy platforms, the partnership aims to expedite the generation and optimization of HCAbs for therapeutic development.
    • The streamlined drug discovery process enabled by this collaboration may lead to faster translation of HCAbs into clinical candidates and ultimately deliver novel treatments for patients in need.
  6. Advancing Precision Medicine:
    • HCAb-based drug discovery aligns with the precision medicine approach, where therapies are tailored to individual patients based on their unique characteristics and disease profiles.
    • The specificity and customizable nature of HCAbs provide an opportunity to develop targeted therapies that address specific disease drivers and personalized patient needs more effectively.


The collaborative partnership between Nona and Dragonfly in HCAb-based drug discovery represents a significant step forward in the quest for innovative therapeutics. By harnessing the unique capabilities of HCAbs, this strategic collaboration holds immense promise for addressing a wide range of diseases and expediting the drug development process. The collaborative efforts of Nona and Dragonfly may pave the way for new treatment options, enabling precision medicine and improving patient outcomes in the years to come.